Natural products with anticonvulsant potentials from Syzygium aromaticum (Myrtaceae)

Chemical investigation of the methanol crude extract dried flower buds Syzygium aromaticum (Myrtaceae) resulted in isolation seven known compounds; oleanolic acid (1), lignoceric (2), β-sitosterol (3), heneicosanoic (4), 5-hydroxy-7-methoxy-2-methylchromone (5), 5-hydroxy-7-methoxy-2,8-dimethylchromone (6) and vanillin (7). Their structures were elucidated using one-dimensional NMR spectroscopy comparison with literature data. The extract, compounds 1-6, revealed significant anticonvulsant activities against seizures induced by picrotoxin, pentylenetetrazole bicuculline, respectively mice. Compound 3 produced 100% protection, compound 2, 5; on other hand, each offered 83.33%, while lowest protection came from 1, 4, 6 (16.66 – 50 00 %). This is first report activity these isolated compounds, 5, 6, 7 aromaticum.